A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five…

• TH
  Texas Health and Human Services Commission
• WF
  Wake Forest University

  Awards: M01 RR07122, RR07122
• JH
  Johns Hopkins University
• NB
  NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
• NI
  National Institute for Health and Care Research
• IC
  Imperial College London
• HÍ
  Háskóli Íslands
• NI
  National Institutes of Health

  Awards: R01 DK066358, DK070941, R01 DK070941, R01 DK053591, 85,86, R01 HL56266, RR07122, DK066358, HHSC268200782096C
• EA
  Economic and Social Research Council

  Award: ES/G007438/1