How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?
Sobell House · University College London · +2 more institutions
Abstract
Transcranial direct current stimulation (tDCS) of the primary motor hand area (M1) can produce lasting polarity-specific effects on corticospinal excitability and motor learning in humans. In 16 healthy volunteers, O positron emission tomography (PET) of regional cerebral blood flow (rCBF) at rest and during finger movements was used to map lasting changes in regional synaptic activity following 10 min of tDCS (+/-1 mA). Bipolar tDCS was given through electrodes placed over the left M1 and right frontopolar cortex. Eight subjects received anodal or cathodal tDCS of the left M1, respectively. When compared to sham tDCS, anodal and cathodal tDCS induced widespread increases and decreases in rCBF in cortical and…
Citation impact
- FWCI
- 10.97
- Percentile
- 100%
- References
- 39
Authors
9- NLNicolas LangCorresponding
Sobell House, University College London, University of Göttingen
- HRHartwig R. Siebner
Sobell House, Christian-Albrechts-Universität zu Kiel, University College London
- NWNick Ward
University College London
- LLLucy Lee
University College London
- MAMichael A. Nitsche
University of Göttingen
Topics & keywords
- Transcranial direct-current stimulation
- Primary motor cortex
- Neuroscience
- Psychology
- Cerebral blood flow
- Premotor cortex
- Motor cortex
- Supplementary motor area
- Good health and well-being