Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
University of California, Irvine · University of Southern California · +39 more institutions
Abstract
The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen's d=-0.46), amygdala (d=-0.31), thalamus (d=-0.31), accumbens (d=-0.25) and intracranial volumes (d=-0.12), as…
Citation impact
- FWCI
- 45.28
- Percentile
- 100%
- References
- 58
Authors
59- FTfor the ENIGMA Schizophrenia Working GroupCorresponding
University of California, Irvine
- TGTheo G.M. van Erp
University of Southern California, University of California, Irvine
- DPDerrek P. Hibar
University of Southern California
- JMJerod M. Rasmussen
University of California, Irvine
- DCDavid C. Glahn
Yale University, Institute for Community Living, Hartford Financial Services (United States)
Topics & keywords
- Putamen
- Neuroimaging
- Thalamus
- Schizophrenia (object-oriented programming)
- Neuroscience
- Psychology
- Brain morphometry
- Ventral pallidum