MorphoGraphX: A platform for quantifying morphogenesis in 4D

Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes. To understand these processes, the evolution of cell shape, proliferation and gene expression must be quantified. This quantification is usually performed either in full 3D, which is computationally expensive and technically challenging, or on 2D planar projections, which introduces geometrical artifacts on highly curved organs. Here we present MorphoGraphX ( www.MorphoGraphX.org), a software that bridges this gap by working directly with curved surface images extracted from 3D data. In addition to traditional 3D image analysis, we have developed algorithms to operate on curved surfaces, such as cell…

• NS
  National Science Foundation
• HF
  Human Frontier Science Program

  Awards: RGY0087/2011, RGP0008/2013
• UO
  University of Birmingham
• DF
  Deutsche Forschungsgemeinschaft
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Awards: CR32I3_143833, CR32I3_132586
• M
  Max-Planck-Gesellschaft

  Award: RGY0087/2011
• NC
  Narodowe Centrum Nauki

  Award: MAESTRO research grant No 2011/02/A/NZ3/00079
• S
  SystemsX.ch
• DF
  Directorate for Biological Sciences
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/L010232/1, BB/L010232/1
• ER
  European Research Council