The Neuropathology of Chronic Traumatic Encephalopathy

Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in association with the play of sports, but CTE has also been reported in association with blast injuries and other neurotrauma. Symptoms of CTE include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases, CTE is diagnosed with certainty only by neuropathological examination of brain tissue. CTE is a tauopathy characterized by the deposition of hyperphosphorylated tau (p-tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small…

• UD
  U.S. Department of Defense
• UD
  U.S. Department of Veterans Affairs
• NO
  National Operating Committee on Standards for Athletic Equipment
• TB
  Traumatic Brain Injury Center of Excellence
• NI
  National Institute on Aging
• NI
  National Institute of Neurological Disorders and Stroke

  Award: 1UO1NS086659-01
• NI
  National Institute of Biomedical Imaging and Bioengineering