The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features
University of California, San Francisco · University Memory and Aging Center · +3 more institutions
Abstract
A 'frontal variant of Alzheimer's disease' has been described in patients with predominant behavioural or dysexecutive deficits caused by Alzheimer's disease pathology. The description of this rare Alzheimer's disease phenotype has been limited to case reports and small series, and many clinical, neuroimaging and neuropathological characteristics are not well understood. In this retrospective study, we included 55 patients with Alzheimer's disease with a behavioural-predominant presentation (behavioural Alzheimer's disease) and a neuropathological diagnosis of high-likelihood Alzheimer's disease (n = 17) and/or biomarker evidence of Alzheimer's disease pathology (n = 44). In addition, we included 29 patients…
Citation impact
- FWCI
- 24.30
- Percentile
- 100%
- References
- 115
Authors
21- RORik OssenkoppeleCorresponding
University of California, San Francisco, University Memory and Aging Center, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of California, Berkeley
- YAYolande A.L. Pijnenburg
Amsterdam UMC Location Vrije Universiteit Amsterdam
- DCDavid C. Perry
University of California, San Francisco, University Memory and Aging Center
- BIBrendan I. Cohn‐Sheehy
University of California, San Francisco, University Memory and Aging Center
- NMNienke M.E. Scheltens
Amsterdam UMC Location Vrije Universiteit Amsterdam
Topics & keywords
- Neuroimaging
- Pathological
- Dysexecutive syndrome
- Neuroscience
- Alzheimer's disease
- Disease
- Psychology
- Medicine
- Good health and well-being