Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health
The University of Melbourne · University of Oxford · +24 more institutions
Abstract
Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital outbreaks and hypervirulent strains associated with severe community-acquired infections. K. pneumoniae is ubiquitous in the environment and can colonize and infect both plants and animals. However, little is known about the population structure of K. pneumoniae, so it is difficult to recognize or understand the emergence of clinically important clones within this highly genetically diverse species. Here we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more than 300 human and animal isolates spanning four…
Citation impact
- FWCI
- 28.19
- Percentile
- 100%
- References
- 71
Authors
28- KEKathryn E. HoltCorresponding
The University of Melbourne
- HWHeiman Wertheim
University of Oxford, Oxford University Clinical Research Unit, Hospital for Tropical Diseases
- RNRuth N. Zadoks
Cornell University, University of Glasgow
- SBStephen Baker
Oxford University Clinical Research Unit, Hospital for Tropical Diseases
- CAChris A. Whitehouse
United States Army Medical Research Institute of Infectious Diseases
Topics & keywords
- Klebsiella pneumoniae
- Virulence
- Antibiotic resistance
- Population structure
- Microbiology
- Diversity (politics)
- Public health
- Genetic diversity
- Good health and well-being