JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles

Mathelier, Anthony; Fornés, Oriol; Arenillas, David J.; Chen, Chih‐Yu; Denay, Grégoire; Lee, Jessica; Shi, Wenqiang; Shyr, Casper; Tan, Ge; Worsley-Hunt, Rebecca; Zhang, Allen W.; Parcy, François; Lenhard, Boris; Sandelin, Albin; Wasserman, Wyeth W.

doi:10.1093/nar/gkv1176

articleNucleic Acids ResearchNov 3, 2015GOLD OA

JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles

AMAnthony Mathelier OFOriol Fornés DJDavid J. Arenillas CCChih‐Yu Chen GDGrégoire Denay

University of British Columbia · Child and Family Research Institute · +7 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

JASPAR (http://jaspar.genereg.net) is an open-access database storing curated, non-redundant transcription factor (TF) binding profiles representing transcription factor binding preferences as position frequency matrices for multiple species in six taxonomic groups. For this 2016 release, we expanded the JASPAR CORE collection with 494 new TF binding profiles (315 in vertebrates, 11 in nematodes, 3 in insects, 1 in fungi and 164 in plants) and updated 59 profiles (58 in vertebrates and 1 in fungi). The introduced profiles represent an 83% expansion and 10% update when compared to the previous release. We updated the structural annotation of the TF DNA binding domains (DBDs) following a published hierarchical…

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Topics

Keywords

Biology
Transcription factor
Database
DNA binding site
Computational biology
Genetics
Computer science
Gene

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