Cancer stem cells in glioblastoma

Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM…

• AC
  American Cancer Society

  Award: IRG-91-022-18
• JS
  James S. McDonnell Foundation
• VF
  V Foundation for Cancer Research

  Award: IRG-91-022-18
• VA
  Voices Against Brain Cancer
• OC
  Ohio Cancer Research Associates
• SF
  Sontag Foundation
• CC
  Cleveland Clinic
• CC
  Comprehensive Cancer Center, City of Hope
• CC
  Case Comprehensive Cancer Center, Case Western Reserve University
• OC
  Ohio Cancer Research
• NI
  National Institutes of Health

  Awards: CA169117, CA171652, CA154130, NS089272, CA191263, NS087913, CA157948, NS083629
• CI
  Canadian Institutes of Health Research