articleNucleic Acids ResearchMay 6, 2015GOLD OA

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

TWTilmann WeberKBKai BlinSDSrikanth DuddelaDKDaniel KrugHUHyun Uk Kim

Technical University of Denmark · Novo Nordisk Foundation · +12 more institutions

PubMed
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Abstract

Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key methodology for novel compound discovery. In 2011, we introduced antiSMASH, a web server and stand-alone tool for the automatic genomic identification and analysis of biosynthetic gene clusters, available at http://antismash.secondarymetabolites.org. Here, we present version 3.0 of antiSMASH, which has undergone major improvements. A full integration of the recently published ClusterFinder algorithm now allows using this probabilistic algorithm to detect putative gene…

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Topics & keywords

Topics
Keywords
  • Biology
  • Genome
  • Computational biology
  • Gene
  • ENCODE
  • XML
  • Identification (biology)
  • Genetics
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