Injectable Self‐Healing Glucose‐Responsive Hydrogels with pH‐Regulated Mechanical Properties

Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical…

• LM
  Leona M. and Harry B. Helmsley Charitable Trust

  Award: 2014PG-T1D002
• NI
  National Institutes of Health

  Award: F32DK101335