Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
MRC Laboratory for Molecular Cell Biology · University College London · +2 more institutions
Abstract
The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cords of Schwann cells. This multicellular process is initiated by hypoxia, selectively sensed by macrophages within the bridge, which via VEGF-A secretion induce a polarized vasculature that relieves the hypoxia. Schwann cells then use the blood vessels as "tracks" to cross the bridge taking regrowing axons with them. Importantly, disrupting the organization of the newly formed blood vessels in vivo,…
Citation impact
- FWCI
- 17.61
- Percentile
- 100%
- References
- 49
Authors
16- ACAnne-Laure Cattin
MRC Laboratory for Molecular Cell Biology, University College London
- JJJemima J. Burden
MRC Laboratory for Molecular Cell Biology, University College London
- LVLucie Van Emmenis
MRC Laboratory for Molecular Cell Biology, University College London
- FEFrancesca E. Mackenzie
University College Hospital, University College London
- JJJulian JA Hoving
MRC Laboratory for Molecular Cell Biology, University College London
Topics & keywords
- Biology
- Schwann cell
- Regeneration (biology)
- Cell biology
- Regenerative process
- Peripheral nervous system
- Anatomy
- Neuroscience