Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Centre for Human Genetics · Churchill Hospital · +8 more institutions
Abstract
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8. Our findings provide insight into the genetic architecture of type 2 diabetes,…
Citation impact
- FWCI
- 181.09
- Percentile
- 100%
- References
- 24
Authors
26- EZEleftheria ZegginiCorresponding
Centre for Human Genetics, Churchill Hospital, University of Bristol, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Peninsula College of Medicine and Dentistry
- MNMichael N. WeedonCorresponding
Centre for Human Genetics, Churchill Hospital, University of Bristol, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Peninsula College of Medicine and Dentistry
- CMCecilia M. LindgrenCorresponding
Centre for Human Genetics, Churchill Hospital, University of Bristol, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Peninsula College of Medicine and Dentistry
- TMTimothy M. FraylingCorresponding
Centre for Human Genetics, Churchill Hospital, University of Bristol, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Peninsula College of Medicine and Dentistry
- KSKatherine S. Elliott
Centre for Human Genetics, Churchill Hospital, University of Bristol, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Peninsula College of Medicine and Dentistry
Topics & keywords
- TCF7L2
- Type 2 diabetes
- Biology
- Genome-wide association study
- Genetics
- CDKN2A
- Genetic association
- Population