The nanoparticle biomolecule corona: lessons learned – challenge accepted?
University of Applied Sciences Mainz · Johannes Gutenberg University Mainz · +5 more institutions
Abstract
Besides the wide use of engineered nanomaterials (NMs) in technical products, their applications are not only increasing in biotechnology and biomedicine, but also in the environmental field. While the physico-chemical properties and behaviour of NMs can be characterized accurately under idealized conditions, this is no longer the case in complex physiological or natural environments. Herein, proteins and other biomolecules rapidly bind to NMs, forming a protein/biomolecule corona that critically affects the NMs' (patho)biological and technical identities. As the corona impacts the in vitro and/or in vivo NM applications in humans and ecosystems, a mechanistic understanding of its relevance and of the…
Citation impact
- FWCI
- 32.74
- Percentile
- 100%
- References
- 222
Authors
6- DDDominic DocterCorresponding
University of Applied Sciences Mainz, Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz
- DWDana Westmeier
University of Applied Sciences Mainz, Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz
- MMMarta Markiewicz
University of Bremen
- SSStefan Stolte
University of Bremen, University of Gdańsk
- SKShirley K. Knauer
Essen University Hospital, University of Duisburg-Essen
Topics & keywords
- Biomolecule
- Nanotechnology
- Corona (planetary geology)
- Nanoparticle
- Chemistry
- Materials science
- Astrobiology
- Physics
- Life in Land