Global Morbidity and Mortality of Leptospirosis: A Systematic Review

BACKGROUND: Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis is a life-threatening disease and recognized as an important cause of pulmonary haemorrhage syndrome, the lack of global estimates for morbidity and mortality has contributed to its neglected disease status. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic review of published morbidity and mortality studies and databases to extract information on disease incidence and case fatality ratios. Linear regression and Monte Carlo modelling were used to obtain age and gender-adjusted estimates of…

• WH
  World Health Organization
• WT
  Wellcome Trust

  Award: 102330/Z/13/Z
• MD
  Ministério da Educação
• NI
  National Institutes of Health

  Awards: T32 AI007172, D43 TW00919, R24 TW007988, R01 AI052473, U01 AI088752, AI007172, R25 TW009338