Pharmaceutical cocrystals: along the path to improved medicines
University of Bern · University of Limerick · +1 more institution
Abstract
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest from crystal engineers and pharmaceutical scientists in the past decade and are now an integral part of the preformulation stage of drug development. This is largely because cocrystals that contain a drug molecule, pharmaceutical cocrystals, can modify physicochemical properties without the need for covalent modification of the drug molecule. This review presents a brief history of cocrystals before addressing recent advances in design, discovery and development of pharmaceutical cocrystals that have occurred since an earlier review published in 2004. We address four aspects of cocrystals: nomenclature; design using…
Citation impact
- FWCI
- 95.26
- Percentile
- 100%
- References
- 186
Authors
4Topics & keywords
- Cocrystal
- Synthon
- Nanotechnology
- Chemistry
- Combinatorial chemistry
- Materials science
- Organic chemistry
- Hydrogen bond
- Good health and well-being