Randomized Controlled Trial of Resection Versus Radiotherapy After Induction Chemotherapy in Stage IIIA-N2 Non-Small-Cell Lung Cancer
Radboud University Nijmegen · Ghent University Hospital · +9 more institutions
Abstract
Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC). We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy.
Selected patients with histologic or cytologic proven stage IIIA-N2 NSCLC were given three cycles of platinum-based induction chemotherapy. Responding patients were subsequently randomly assigned to surgical resection or radiotherapy. Survival curves were estimated using Kaplan-Meier analyses from time of randomization.
Citation impact
- FWCI
- 36.34
- Percentile
- 100%
- References
- 54
Authors
12- JPJan P. van MeerbeeckCorresponding
Radboud University Nijmegen, Ghent University Hospital, Radboud University Medical Center, The Netherlands Cancer Institute, Ghent University, Antwerp University Hospital, St. Antonius Ziekenhuis, European Organisation for Research and Treatment of Cancer, Radiotherapiegroep, Jeroen Bosch Ziekenhuis, Vrije Universiteit Amsterdam
- GKG. Kramer
Radboud University Nijmegen, Ghent University Hospital, Radboud University Medical Center, The Netherlands Cancer Institute, Antwerp University Hospital, St. Antonius Ziekenhuis, European Organisation for Research and Treatment of Cancer, Radiotherapiegroep, Jeroen Bosch Ziekenhuis, Vrije Universiteit Amsterdam
- PVPaul Van Schil
Radboud University Nijmegen, Ghent University Hospital, Radboud University Medical Center, The Netherlands Cancer Institute, Antwerp University Hospital, St. Antonius Ziekenhuis, European Organisation for Research and Treatment of Cancer, Radiotherapiegroep, Jeroen Bosch Ziekenhuis, Vrije Universiteit Amsterdam
- CLCathérine Legrand
Radboud University Nijmegen, Ghent University Hospital, Radboud University Medical Center, The Netherlands Cancer Institute, Antwerp University Hospital, St. Antonius Ziekenhuis, European Organisation for Research and Treatment of Cancer, Radiotherapiegroep, Jeroen Bosch Ziekenhuis, Vrije Universiteit Amsterdam
- EFEgbert F. Smit
Radboud University Nijmegen, Ghent University Hospital, Radboud University Medical Center, The Netherlands Cancer Institute, Antwerp University Hospital, St. Antonius Ziekenhuis, European Organisation for Research and Treatment of Cancer, Radiotherapiegroep, Jeroen Bosch Ziekenhuis, Vrije Universiteit Amsterdam
Topics & keywords
- Medicine
- Radiation therapy
- Surgery
- Induction chemotherapy
- Chemotherapy
- Lung cancer
- Hazard ratio
- Stage (stratigraphy)
- Good health and well-being