Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Universität Ulm · University of Münster · +7 more institutions
Abstract
Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte subsets have been characterized minimally. In this study we identify three subpopulations of mouse monocytes that can be distinguished by differential expression of Ly-6C, CD43, CD11c, MBR, and CD62L. The subsets share the characteristics of extensive phagocytosis, similar expression of M-CSF receptor (CD115), and development into macrophages upon M-CSF stimulation. By eliminating blood monocytes with dichloromethylene-bisphosphonate-loaded liposomes and monitoring their repopulation, we showed a…
Citation impact
- FWCI
- 9.68
- Percentile
- 100%
- References
- 33
Authors
7- CSCord SunderkötterCorresponding
Universität Ulm, University of Münster, University Hospital Münster, University Hospital Ulm
- TNTatjana Nikolić
Erasmus MC, Erasmus University Rotterdam
- MJMarilyn J. Dillon
University of Oklahoma Medical Center, OU Health, University of Oklahoma Health Sciences Center
- NVNico van Rooijen
- MSMartin Stehling
University of Münster, University Hospital Münster
Topics & keywords
- CD11c
- Immunology
- Monocyte
- Inflammation
- Bone marrow
- Biology
- Monocytosis
- Phagocytosis
- Good health and well-being