Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes
TLThe Look AHEAD Research Group
John Brown University · TiGenix (Spain)
Indexed incrossrefpubmed
Abstract
Background
Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease remain unknown. We examined whether an intensive lifestyle intervention for weight loss would decrease cardiovascular morbidity and mortality among such patients.
Methods
In 16 study centers in the United States, we randomly assigned 5145 overweight or obese patients with type 2 diabetes to participate in an intensive lifestyle intervention that promoted weight loss through decreased caloric intake and increased physical activity (intervention group) or to receive diabetes support and education (control group). The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina during a maximum follow-up of 13.5 years.
Citation impact
2,871
total citations
- FWCI
- 245.06
- Percentile
- 100%
- References
- 26
Citations per year
Authors
1- TLThe Look AHEAD Research GroupCorresponding
John Brown University, TiGenix (Spain)
Topics & keywords
Topics
Keywords
- Medicine
- Overweight
- Weight loss
- Type 2 diabetes
- Diabetes mellitus
- Obesity
- Disease
- Intervention (counseling)
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.
Funding
- UDU.S. Department of Health and Human Services
- UDU.S. Department of Veterans AffairsAward: M01RR01346
- MGMassachusetts General HospitalAwards: DK57151, DK57219, DK57182, UL1 RR 024153, M01RR01066, DK57008, DK57178, DK57154, M01RR00051, DK57136, P30 DK48520, DK57171, DK57177, DK57149, DK57002, M01RR000056, DK56992, DK 046204, M01RR02719, M01RR01346, DK56990, DK57131, M01RR0021140, DK57078, DK57135
- MIMassachusetts Institute of TechnologyAwards: DK 046204, P30 DK48520, DK57182, DK57154, DK57002, DK57149, DK57178, M01RR01346, DK57135, DK57171, DK57151, DK57078, M01RR02719, UL1 RR 024153, DK57008, M01RR01066, M01RR000056, DK56990, DK57177, DK56992, M01RR0021140, DK57219, DK57136, DK57131, M01RR00051
- JHJohns Hopkins UniversityAward: M01RR02719
- UOUniversity of PittsburghAwards: DK57131, DK57008, DK57154, M01RR01346, M01RR01066, DK57078, DK56990, DK57178, DK57002, DK57177, DK56992, P30 DK48520, DK 046204, M01RR02719, DK57151, M01RR0021140, DK57149, M01RR000056, UL1 RR 024153, M01RR00051, DK57136, DK57171, DK57219, DK57182, DK57135
- NINational Institutes of HealthAwards: DK56992, DK48520, DK57136, P30 DK48520, DK57219, M01RR01066, DK57078, M01RR0021140, M01RR00051, DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, M01RR000056, DK57002, DK 046204, M01RR02719, DK57171, DK57151, DK57008, 046204, DK57177, DK57178, DK56990, DK57154, DK57131, DK57182, DK57135, M01RR01346, UL1 RR 024153, DK57149
- CFCenters for Disease Control and PreventionAwards: M01RR02719, M01RR000056, DK57135, DK57154, DK57131, M01RR00051, DK 046204, DK57008, M01RR01346, DK56992, M01RR0021140, DK57177, DK57151, P30 DK48520, M01RR01066, UL1 RR 024153, DK57182, DK57171, DK56990, DK57136, DK57149, DK57078, DK57219, DK57002, DK57178
- NHNational Heart, Lung, and Blood InstituteAwards: DK57219, M01RR02719, DK57131, DK57154, DK57151, DK56992, DK57078, M01RR000056, DK57177, M01RR01346, M01RR0021140, DK 046204, DK57182, DK57002, DK57149, M01RR01066, UL1 RR 024153, DK57008, DK57135, P30 DK48520, DK57136, DK57178, DK56990, DK57171, M01RR00051
- NINational Institute of Nursing ResearchAwards: M01RR01346, DK57219, DK57008, M01RR0021140, DK57002, DK57177, M01RR000056, M01RR01066, DK57171, DK57182, DK57135, DK57131, DK 046204, DK57151, P30 DK48520, UL1 RR 024153, M01RR00051, DK57136, DK56990, DK57178, DK57078, DK56992, DK57149, M01RR02719
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAwards: M01RR0021140, DK48520, P30 DK48520, DK57149, DK57182, M01RR000056, M01RR01066, DK57008, DK57219, DK 046204, DK57078, M01RR02719, M01RR01346, DK57131, UL1 RR 024153, DK56992, M01RR00051, DK57136
- NCNational Center on Minority Health and Health DisparitiesAwards: DK57136, M01RR01066, M01RR00051, DK57171, M01RR02719, M01RR000056, DK57182, DK57154, DK57177, DK 046204, DK57135, M01RR0021140, UL1 RR 024153, DK57008, DK57178, DK57002, DK57151, P30 DK48520, DK56990, DK57078, DK56992, DK57149, M01RR01346, DK57219, DK57131
- OOOffice of Research on Women's HealthAwards: M01RR02719, DK57008, DK57135, DK56990, DK57002, P30 DK48520, DK57177, DK56992, DK57182, DK57151, DK57149, DK57219, DK57078, M01RR000056, M01RR01346, DK57171, UL1 RR 024153, DK57178, M01RR01066, M01RR00051, DK57154, DK57136, DK57131, DK 046204, M01RR0021140
- NINational Institute on Minority Health and Health Disparities