IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis
Tokyo Medical University · Tokyo University of Science · +1 more institution
Abstract
IL-17 is a proinflammatory cytokine that activates T cells and other immune cells to produce a variety of cytokines, chemokines, and cell adhesion molecules. This cytokine is augmented in the sera and/or tissues of patients with contact dermatitis, asthma, and rheumatoid arthritis. We previously demonstrated that IL-17 is involved in the development of autoimmune arthritis and contact, delayed, and airway hypersensitivity in mice. As the expression of IL-17 is also augmented in multiple sclerosis, we examined the involvement of this cytokine in these diseases using IL-17(-/-) murine disease models. We found that the development of experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple…
Citation impact
- FWCI
- 41.44
- Percentile
- 100%
- References
- 55
Authors
8- YKYutaka KomiyamaCorresponding
Tokyo Medical University, Tokyo University of Science, The University of Tokyo
- SNSusumu Nakae
Tokyo Medical University, Tokyo University of Science, The University of Tokyo
- TMTaizo Matsuki
Tokyo Medical University, Tokyo University of Science, The University of Tokyo
- ANAya Nambu
Tokyo Medical University, Tokyo University of Science, The University of Tokyo
- HIHarumichi Ishigame
Tokyo Medical University, Tokyo University of Science, The University of Tokyo
Topics & keywords
- Experimental autoimmune encephalomyelitis
- Immunology
- Adoptive cell transfer
- Myelin oligodendrocyte glycoprotein
- Interleukin 17
- Cytokine
- T cell
- Multiple sclerosis
- Good health and well-being