Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol
University of Reading · Istituto di Chimica Biomolecolare
Abstract
Endocannabinoids are implicated in appetite and body weight regulation. In rodents, anandamide stimulates eating by actions at central CB1 receptors, and hypothalamic endocannabinoids may be under the negative control of leptin. However, changes to brain endocannabinoid levels in direct relation to feeding or changing nutritional status have not been investigated. We measured anandamide and 2-arachidonoyl glycerol (2-AG) levels in feeding-associated brain regions of rats, during fasting, feeding of a palatable food, or after satiation. Endocannabinoid levels were compared to those in rats fed ad libitum, at a point in their daily cycle when motivation to eat was absent. Fasting increased levels of anandamide…
Citation impact
- FWCI
- 17.00
- Percentile
- 100%
- References
- 57
Authors
4Topics & keywords
- Endocannabinoid system
- Endocrinology
- Internal medicine
- Cannabinoid receptor
- Forebrain
- Nucleus accumbens
- Anandamide
- Cannabinoid
- Zero hunger