Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities
Johannes Gutenberg University Mainz · University Medical Center of the Johannes Gutenberg University Mainz · +2 more institutions
Abstract
Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can cause oxidative damage to DNA, proteins, and membrane lipids. Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. Certain reactive oxygen species, such as hydrogen peroxide, are also essential for growth factor-mediated signal transduction, mitochondrial function, and maintenance of normal thiol redox-balance. Thus, by limiting hydrogen peroxide accumulation, GPx-1 also modulates these processes. This review explores the molecular…
Citation impact
- FWCI
- 14.11
- Percentile
- 100%
- References
- 422
Authors
3Topics & keywords
- Selenocysteine
- Glutathione peroxidase
- Reactive oxygen species
- Antioxidant
- Biochemistry
- Oxidative stress
- Chemistry
- Hydrogen peroxide
- Life below water