Interaction of Gold Nanoparticles with Common Human Blood Proteins
Center for Biologics Evaluation and Research · United States Food and Drug Administration · +3 more institutions
Abstract
In order to better understand the physical basis of the biological activity of nanoparticles (NPs) in nanomedicine applications and under conditions of environmental exposure, we performed an array of photophysical measurements to quantify the interaction of model gold NPs having a wide range of NP diameters with common blood proteins. In particular, absorbance, fluorescence quenching, circular dichroism, dynamic light scattering, and electron microscopy measurements were performed on surface-functionalized water-soluble gold NPs having a diameter range from 5 to 100 nm in the presence of common human blood proteins: albumin, fibrinogen, gamma-globulin, histone, and insulin. We find that the gold NPs strongly…
Citation impact
- FWCI
- 23.15
- Percentile
- 100%
- References
- 70
Authors
7- SHSilvia H. De Paoli LacerdaCorresponding
Center for Biologics Evaluation and Research, United States Food and Drug Administration
- JJJung Jin Park
University of Maryland, College Park
- CMCurt Meuse
National Institute of Standards and Technology
- DPDenis Pristinski
National Institute of Standards and Technology
- MLMatthew L. Becker
University of Akron
Topics & keywords
- Circular dichroism
- Colloidal gold
- Nanoparticle
- Chemistry
- Dynamic light scattering
- Biophysics
- Nanomedicine
- Human serum albumin