Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets
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Abstract
Hepatic fibrosis is a scarring process that is associated with an increased and altered deposition of extracellular matrix in liver. At the cellular and molecular level, this progressive process is mainly characterized by cellular activation of hepatic stellate cells and aberrant activity of transforming growth factor-beta1 and its downstream cellular mediators. Although the cellular responses to this cytokine are complex, the signalling pathways of this pivotal cytokine during the fibrogenic response and its connection to other signal cascades are now understood in some detail. Based on the current advances in understanding the pleiotropic reactions during fibrogenesis, various inhibitors of transforming…
Citation impact
713
total citations
- FWCI
- 20.19
- Percentile
- 100%
- References
- 142
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Hepatic stellate cell
- Hepatic fibrosis
- Transforming growth factor
- Fibrosis
- Cytokine
- Extracellular matrix
- Growth factor
- Signal transduction
UN Sustainable Development Goals
- Good health and well-being
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