Suppression of Central Sleep Apnea by Continuous Positive Airway Pressure and Transplant-Free Survival in Heart Failure
Western University · Dalhousie University · +5 more institutions
Abstract
Background— In the main analysis of the Canadian Continuous Positive Airway Pressure (CPAP) for Patients with Central Sleep Apnea (CSA) and Heart Failure Trial (CANPAP), CPAP had no effect on heart transplant–free survival; however, CPAP only reduced the mean apnea-hypopnea index to 19 events per hour of sleep, which remained above the trial inclusion threshold of 15. This stratified analysis of CANPAP tested the hypothesis that suppression of CSA below this threshold by CPAP would improve left ventricular ejection fraction and heart transplant–free survival. Methods and Results— Of the 258 heart failure patients with CSA in CANPAP, 110 of the 130 randomized to the control group and 100 of the 128 randomized…
Citation impact
- FWCI
- 21.30
- Percentile
- 100%
- References
- 29
Authors
15- MAMichael ArztCorresponding
Western University, Dalhousie University, University of British Columbia, University of Calgary, Université Laval, McGill University, University of Regensburg
- JSJohn S. Floras
Western University, Dalhousie University, University of British Columbia, University of Calgary, Université Laval, McGill University, University of Regensburg
- AGAlexander G. Logan
Western University, Dalhousie University, University of British Columbia, University of Calgary, Université Laval, McGill University, University of Regensburg
- RJR. John Kimoff
Western University, Dalhousie University, University of British Columbia, University of Calgary, Université Laval, McGill University, University of Regensburg
- FSFrédéric Sériès
Western University, Dalhousie University, University of British Columbia, University of Calgary, Université Laval, McGill University, University of Regensburg
Topics & keywords
- Medicine
- Continuous positive airway pressure
- Ejection fraction
- Hazard ratio
- Heart failure
- Cardiology
- Apnea–hypopnea index
- Internal medicine
- Good health and well-being