Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology

Antibiotic resistance is a dire clinical problem with important ecological dimensions. While antibiotic resistance in human pathogens continues to rise at alarming rates, the impact of environmental resistance on human health is still unclear. To investigate the relationship between human-associated and environmental resistomes, we analyzed functional metagenomic selections for resistance against 18 clinically relevant antibiotics from soil and human gut microbiota as well as a set of multidrug-resistant cultured soil isolates. These analyses were enabled by Resfams, a new curated database of protein families and associated highly precise and accurate profile hidden Markov models, confirmed for antibiotic…

• NS
  National Science Foundation

  Award: DGE-11143954
• NI
  National Institutes of Health

  Awards: DP2DK098089, T32 HG000045, R01GM099538, HG000045
• NH
  National Human Genome Research Institute

  Awards: HG000045, T32 HG000045
• NI
  National Institute of General Medical Sciences

  Awards: GM 007067, R01GM099538, DP2DK098089, 007067
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: DP2DK098089