articleJournal of Pharmacology and Experimental TherapeuticsAug 21, 2004Closed access

Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6

ZDZeruesenay DestaBABryan A. WardNSNadia SoukhovaDADavid A. Flockhart

Indiana University School of Medicine · Indiana University – Purdue University Indianapolis · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

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644
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17.87
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100%
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42
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Authors

4

Topics & keywords

Topics
Keywords
  • CYP3A
  • Biotransformation
  • Desmethyl
  • Metabolite
  • Chemistry
  • Cytochrome P450
  • CYP3A4
  • Primary metabolite
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