reviewNew England Journal of MedicineMar 12, 2008GREEN OA

Epigenetics in Cancer

MEManel Esteller

Centro de Investigación del Cáncer · Spanish National Cancer Research Centre

PubMed
Indexed incrossrefdatacitepubmed

Abstract

Gene transcription can be activated or inhibited by a reversible modification of the gene; this modification is termed an epigenetic change. This account of epigenetics in cancer reviews the mechanisms and consequences of epigenetic changes in cancer cells and concludes with the implications of these changes for the diagnosis, prognosis, and treatment of cancer.

Citation impact

3,643
total citations
FWCI
113.70
Percentile
100%
References
103
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Epigenetics
  • Medicine
  • Cancer
  • Epigenesis
  • Gene
  • Cancer epigenetics
  • Transcription factor
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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