Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

Although increased external load initially induces cardiac hypertrophy with preserved contractility, sustained overload eventually leads to heart failure through poorly understood mechanisms. Here we describe a conditional transgenic system in mice characterized by the sequential development of adaptive cardiac hypertrophy with preserved contractility in the acute phase and dilated cardiomyopathy in the chronic phase following the induction of an activated Akt1 gene in the heart. Coronary angiogenesis was enhanced during the acute phase of adaptive cardiac growth but reduced as hearts underwent pathological remodeling. Enhanced angiogenesis in the acute phase was associated with mammalian target of…

• AH
  American Heart Association
• SO
  School of Medicine, Boston University
• NI
  National Institutes of Health

  Awards: AR40197, AG15052, AG17241, HL77774