CD4 T cells: fates, functions, and faults

In 1986, Mosmann and Coffman identified 2 subsets of activated CD4 T cells, Th1 and Th2 cells, which differed from each other in their pattern of cytokine production and their functions. Our understanding of the importance of the distinct differentiated forms of CD4 T cells and of the mechanisms through which they achieve their differentiated state has greatly expanded over the past 2 decades. Today at least 4 distinct CD4 T-cell subsets have been shown to exist, Th1, Th2, Th17, and iTreg cells. Here we summarize much of what is known about the 4 subsets, including the history of their discovery, their unique cytokine products and related functions, their distinctive expression of cell surface receptors and…

• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases
• NI
  National Institutes of Health
• NI
  National Institute of Allergy and Infectious Diseases
• ND
  NHLBI Division of Intramural Research