The publisher or authors have withdrawn this paper. Cite with extreme caution; check the publisher's notice for the reason.
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Johns Hopkins University · Johns Hopkins Medicine · +1 more institution
Abstract
Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death. Autophagy is a process by which cytoplasmic organelles can be catabolized either…
Citation impact
- FWCI
- 52.24
- Percentile
- 100%
- References
- 48
Authors
8- HZHuafeng Zhang
Johns Hopkins University, Johns Hopkins Medicine
- MBMarta Bosch‐Marcé
Johns Hopkins University, Johns Hopkins Medicine
- LALarissa A. Shimoda
Johns Hopkins University, Johns Hopkins Medicine
- YSYee Sun Tan
Johns Hopkins University, Johns Hopkins Medicine
- JHJin Hyen Baek
Johns Hopkins University, Johns Hopkins Medicine
Topics & keywords
- Autophagy
- Cell biology
- Mitochondrion
- ATG5
- Biology
- Hypoxia (environmental)
- Programmed cell death
- Organelle
- Affordable and clean energy