Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Istituto Oncologico Veneto · Istituti di Ricovero e Cura a Carattere Scientifico · +5 more institutions
Abstract
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+IL-4 receptor alpha+ (CD11b+IL-4Ralpha+), inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-gamma released from T lymphocytes. CD11b+IL-4Ralpha+ cells produced IL-13 and IFN-gamma and integrated the downstream signals of these cytokines to trigger the molecular pathways…
Citation impact
- FWCI
- 18.26
- Percentile
- 100%
- References
- 53
Authors
12- GGGiovanna GallinaCorresponding
Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico
- LDLuigi Dolcetti
Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico
- PSPaolo Serafini
Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center
- CDCarmela De Santo
Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Oncologico Veneto
- IMIlaria Marigo
Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Oncologico Veneto
Topics & keywords
- Immune system
- Immunology
- CD8
- Integrin alpha M
- Biology
- Cytotoxic T cell
- Cancer research
- Immunotherapy
- Good health and well-being