Rotenone, Paraquat, and Parkinson’s Disease
Parkinson's Institute and Clinical Center · National Institutes of Health · +10 more institutions
Abstract
Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans.
Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans.
Citation impact
- FWCI
- 54.11
- Percentile
- 100%
- References
- 62
Authors
20- CMCaroline M. TannerCorresponding
Parkinson's Institute and Clinical Center
- FKFreya Kamel
National Institutes of Health, National Institute of Environmental Health Sciences
- GWG. Webster Ross
VA Pacific Islands Health Care System
- JAJane A. Hoppin
National Institutes of Health, National Institute of Environmental Health Sciences
- SMSamuel M. Goldman
Parkinson's Institute and Clinical Center
Topics & keywords
- Rotenone
- Parkinson's disease
- Paraquat
- Medicine
- Disease
- Biology
- Pathology
- Mitochondrion