Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease
University of California, San Francisco · Neurological Surgery
Abstract
By examining Parkinson's disease patients undergoing deep brain stimulation (DBS) implantation surgery, this study shows that therapeutic DBS acts on the primary motor cortex to reversibly reduce excessive coupling between the phase of the beta rhythm and the amplitude of broadband activity over a similar time course as the reduction in parkinsonian motor signs. Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS on cortical function using invasive cortical recordings in Parkinson's disease (PD) patients undergoing DBS implantation surgery. In the primary motor cortex of PD…
Citation impact
- FWCI
- 46.90
- Percentile
- 100%
- References
- 62
Authors
7- CDCoralie de HemptinneCorresponding
University of California, San Francisco, Neurological Surgery
- NCNicole C. Swann
University of California, San Francisco, Neurological Surgery
- JLJill L. Ostrem
University of California, San Francisco
- ERElena Ryapolova-Webb
University of California, San Francisco, Neurological Surgery
- MSMarta San Luciano
University of California, San Francisco
Topics & keywords
- Deep brain stimulation
- Neuroscience
- Primary motor cortex
- Parkinson's disease
- Motor cortex
- Basal ganglia
- Stimulation
- Cortex (anatomy)
- Good health and well-being