Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Although members of the fibroblast growth factor (FGF) family and their receptors have well-established roles in embryogenesis, their contributions to adult physiology remain relatively unexplored. Here, we use real-time quantitative PCR to determine the mRNA expression patterns of all 22 FGFs, the seven principal FGF receptors (FGFRs), and the three members of the Klotho family of coreceptors in 39 different mouse tissues. Unsupervised hierarchical cluster analysis of the mRNA expression data reveals that most FGFs and FGFRs fall into two groups the expression of which is enriched in either the central nervous system or reproductive and gastrointestinal tissues. Interestingly, the FGFs that can act as…

• HH
  Howard Hughes Medical Institute

  Awards: I-1558, I-1275
• WF
  Welch Foundation

  Awards: I-1275, I-1558, GM007062
• NI
  National Institutes of Health

  Awards: DK067158, U19DK62434, I-1275, I-1558, GM007062, AG19712