SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
Children's Nutrition Research Center at Baylor College of Medicine · The University of Texas MD Anderson Cancer Center
Abstract
The sirtuin family of nicotinamide adenine dinucleotide-dependent (NAD) deacetylases plays an important role in aging and metabolic regulation. In yeast, the Sir2 gene and its homolog Hst2 independently mediate the action of caloric restriction on lifespan extension. The mammalian Sir2 ortholog, SIRT1, is up-regulated by caloric restriction and deacetylates a variety of substrates, including histones and the forkhead box O (FOXO) transcription factors. The mammalian ortholog of Hst2, SIRT2, was shown to co-localize with microtubules and functions as alpha-tubulin deacetylase. During G2/M phase, SIRT2 proteins enter nuclei and deacetylate histones. We report here that the expression of SIRT2 is elevated in the…
Citation impact
- FWCI
- 16.81
- Percentile
- 100%
- References
- 53
Authors
4- FWFei WangCorresponding
Children's Nutrition Research Center at Baylor College of Medicine
- MNMargaret Nguyen
Children's Nutrition Research Center at Baylor College of Medicine
- FXF. Xiao‐Feng Qin
The University of Texas MD Anderson Cancer Center
- QTQiang Tong
Children's Nutrition Research Center at Baylor College of Medicine
Topics & keywords
- SIRT2
- Sirtuin
- Biology
- NAD+ kinase
- Cell biology
- Oxidative stress
- Acetylation
- Transcription factor