Calcium/Vitamin D Supplementation and Cardiovascular Events
University of North Carolina at Chapel Hill · Brigham and Women's Hospital · +10 more institutions
Abstract
Individuals with vascular or valvular calcification are at increased risk for coronary events, but the relationship between calcium consumption and cardiovascular events is uncertain. We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation. METHODS AND RESULTS: We randomized 36,282 postmenopausal women 50 to 79 years of age at 40 clinical sites to calcium carbonate 500 mg with vitamin D 200 IU twice daily or to placebo. Cardiovascular disease was a prespecified secondary efficacy outcome. During 7 years of follow-up, myocardial infarction or coronary heart disease death was confirmed for 499 women assigned to calcium/vitamin D and 475 women assigned to placebo (hazard ratio, 1.04; 95% confidence interval, 0.92 to 1.18). Stroke was confirmed among 362 women assigned to calcium/vitamin D and 377 assigned to placebo (hazard ratio, 0.95; 95% confidence interval, 0.82 to 1.10). In subgroup analyses, women with higher total calcium intake (diet plus supplements) at baseline were not at higher risk for coronary events (P=0.91 for interaction) or stroke (P=0.14 for interaction) if assigned to active calcium/vitamin D.
Calcium/vitamin D supplementation neither increased nor decreased coronary or cerebrovascular risk in generally healthy postmenopausal women over a 7-year use period.
Citation impact
- FWCI
- 28.48
- Percentile
- 100%
- References
- 44
Authors
11- JHJudith HsiaCorresponding
University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Kaiser Permanente, Harvard University, University of Tennessee Health Science Center, George Washington University, University of Washington, University of California San Diego, Fred Hutch Cancer Center, Cancer Research Center, University at Buffalo, State University of New York
- GHGerardo Heiss
University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Kaiser Permanente, Harvard University, University of Tennessee Health Science Center, George Washington University, University of Washington, University of California San Diego, Fred Hutch Cancer Center, Cancer Research Center, University at Buffalo, State University of New York
- HRHong Ren
University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Kaiser Permanente, Harvard University, University of Tennessee Health Science Center, George Washington University, University of Washington, University of California San Diego, Fred Hutch Cancer Center, Cancer Research Center, University at Buffalo, State University of New York
- MAMatthew Allison
University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Kaiser Permanente, Harvard University, University of Tennessee Health Science Center, George Washington University, University of Washington, University of California San Diego, Fred Hutch Cancer Center, Cancer Research Center, University at Buffalo, State University of New York
- NCNancy C. Dolan
University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Kaiser Permanente, Harvard University, University of Tennessee Health Science Center, George Washington University, University of Washington, University of California San Diego, Fred Hutch Cancer Center, Cancer Research Center, University at Buffalo, State University of New York
Topics & keywords
- Medicine
- Calcium
- Calcium supplementation
- Vitamin D and neurology
- Internal medicine
- Endocrinology
- Cardiology
- Physiology
- Good health and well-being