Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells
Inserm · Établissement Français du Sang · +4 more institutions
Abstract
Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells that are the subject of intense investigation in regenerative medicine. In addition, MSCs possess immunomodulatory properties with therapeutic potential to prevent graft-versus-host disease (GvHD) in allogeneic hematopoietic cell transplantation. Indeed, MSCs can inhibit natural killer (NK) function, modulate dendritic cell maturation, and suppress allogeneic T-cell response. Here, we report that the nonclassic human leukocyte antigen (HLA) class I molecule HLA-G is responsible for the immunomodulatory properties of MSCs. Our data show that MSCs secrete the soluble isoform HLA-G5 and that such secretion is interleukin-10-dependent.…
Citation impact
- FWCI
- 13.92
- Percentile
- 100%
- References
- 54
Authors
12- ZSZohair Selmani
Inserm, Établissement Français du Sang, Université de franche-comté
- ANAbderrahim Naji
Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Hôpital Saint-Louis
- IZInès Zidi
Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Hôpital Saint-Louis
- BFBenoı̂t Favier
Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Hôpital Saint-Louis
- ÉGÉmilie Gaiffe
Inserm, Établissement Français du Sang, Université de franche-comté
Topics & keywords
- Biology
- Mesenchymal stem cell
- Cell biology
- Secretion
- Function (biology)
- Immunology
- Stem cell
- Biochemistry
- Good health and well-being