Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

Aldehydes are highly reactive molecules. While several non-P450 enzyme systems participate in their metabolism, one of the most important is the aldehyde dehydrogenase (ALDH) superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation.

This article presents a review of what is currently known about each member of the human ALDH superfamily including the pathophysiological significance of these enzymes.