articleNature BiotechnologySep 3, 2014GREEN OA

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

JGJohn G. DoenchEHElla HartenianDBDaniel B. GrahamZTZuzana TóthováMHMudra Hegde

Broad Institute · Massachusetts General Hospital · +1 more institution

PubMed
Indexed incrossrefpubmed

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1,717
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57.33
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100%
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Authors

10

Topics & keywords

Topics
Keywords
  • CRISPR
  • Guide RNA
  • Cas9
  • Genome editing
  • Biology
  • Palindrome
  • Gene
  • Computational biology
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