articleJournal of the American Chemical SocietyAug 8, 2008Closed access

Nanoscale Coordination Polymers for Platinum-Based Anticancer Drug Delivery

WJWilliam J. RieterKMKimberly M. PottKTK. Taylor-PashowWLWenbin Lin

University of North Carolina at Chapel Hill

PubMed
Indexed incrossrefpubmed

Abstract

Pt-containing nanoscale coordination polymer (NCP) particles with the formula of Tb2(DSCP)3(H2O)12 (where DSCP represents disuccinatocisplatin), NCP-1, were precipitated from an aqueous solution of Tb3+ ions and DSCP bridging ligands via the addition of a poor solvent. SEM and TEM images showed that as-synthesized NCP-1 exhibited a spherical morphology with a DLS diameter of 58.3 +/- 11.3 nm. NCP-1 particles were stabilized against rapid dissolution in water by encapsulation in shells of amorphous silica. The resulting silica-coated particles NCP-1' exhibited significantly longer half-lives for DSCP release from the particles (a t1/2 of 9 h for NCP-1' with 7 nm silica coating vs t1/2 of 1 h for as-synthesized…

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4

Topics & keywords

Topics
Keywords
  • Chemistry
  • Aqueous solution
  • Nanoparticle
  • Drug delivery
  • Polymer
  • Cytotoxicity
  • Cisplatin
  • Nuclear chemistry
UN Sustainable Development Goals
  • Clean water and sanitation
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