Regulation of ferritin genes and protein

Increasingly, perturbations in cellular iron and ferritin are emerging as an important element in the pathogenesis of disease. These changes in ferritin are important not only in the classic diseases of iron acquisition, transport, and storage, such as primary hemochromatosis, but also in diseases characterized by inflammation, infection, injury, and repair. Among these are some of the most common diseases that afflict mankind: neurodegenerative diseases such as Parkinson disease 1 and Alzheimer disease, 2 vascular diseases such as cardiac and neuronal ischemia-reperfusion injury, We are just beginning to learn the mechanisms and implications of alterations in ferritin and iron homeostasis from these natural…

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  National Institutes of Health