Microbiota is essential for social development in the mouse

Limbic afferents. 7 Furthermore, experiences of DBS in man also suggest a persisting modulation of synaptic plasticity, 2 as indicated by a lasting abstinence-sustaining effect of NAcc DBS even after explantation of the stimulation device.On the basis of these findings, we hypothesize that NAcc DBS facilitates heroin and methadone abstinence by promoting neuroplastic changes in dopaminergic neurons.It remains unclear whether the observed beneficial effects allow a generalization to other forms of substance addictions.However, the fact that the patients' comorbid drug consumption did not decline challenges this view.The interpretation of this circumstance in terms of a cross addiction, developing because heroin…

• EL
  Eli Lilly and Company
• A
  AstraZeneca
• SF
  Science Foundation Ireland

  Awards: 02/CE/B124, 07/CE/B1368
• HL
  H. Lundbeck A/S