Medium- and short-chain dehydrogenase/reductase gene and protein families

Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. SDR enzymes have critical roles in lipid, amino acid, carbohydrate, cofactor, hormone and xenobiotic metabolism as well as in redox sensor mechanisms. Sequence identities are low, and the most conserved feature is an alpha/beta folding pattern with a central beta sheet flanked by 2 - 3 alpha-helices from each side, thus a classical Rossmannfold motif for nucleotide binding. The conservation of this element and an active site, often with an Asn-Ser-Tyr-Lys tetrad, provides a platform for enzymatic activities encompassing several EC classes,…

• G
  GlaxoSmithKline
• OI
  Ontario Innovation Trust
• GC
  Genome Canada
• WT
  Wellcome Trust

  Award: 1097737
• OG
  Ontario Genomics
• OG
  Ontario Genomics Institute
• SF
  Stiftelsen för Strategisk Forskning
• KI
  Karolinska Institutet
• KO
  Knut och Alice Wallenbergs Stiftelse
• NN
  Novo Nordisk
• V
  Vetenskapsrådet

  Award: 1097737