Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes

Gregg, Edward W.; Chen, Haiying; Wagenknecht, Lynne E.; Clark, Jeanne M.; Delahanty, Linda M.; Bantle, John P.; Pownall, Henry J.; Johnson, Karen; Safford, Monika M.; Kitabchi, Abbas E.; Pi‐Sunyer, F. Xavier; Wing, Rena R.; Bertoni, Alain G.

doi:10.1001/jama.2012.67929

articleJAMADec 19, 2012BRONZE OA

Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes

EWEdward W. Gregg HCHaiying Chen LELynne E. Wagenknecht JMJeanne M. Clark LMLinda M. Delahanty

Centers for Disease Control and Prevention · Wake Forest University · +9 more institutions

PubMed

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Abstract

CONTEXT: The frequency of remission of type 2 diabetes achievable with lifestyle intervention is unclear. OBJECTIVE: To examine the association of a long-term intensive weight-loss intervention with the frequency of remission from type 2 diabetes to prediabetes or normoglycemia. DESIGN, SETTING, AND PARTICIPANTS: Ancillary observational analysis of a 4-year randomized controlled trial (baseline visit, August 2001-April 2004; last follow-up, April 2008) comparing an intensive lifestyle intervention (ILI) with a diabetes support and education control condition (DSE) among 4503 US adults with body mass index of 25 or higher and type 2 diabetes. INTERVENTIONS: Participants were randomly assigned to receive the…

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745

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Topics

Keywords

Medicine
Prediabetes
Type 2 diabetes
Diabetes mellitus
Randomized controlled trial
Body mass index
Weight loss
Internal medicine

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