Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
Institute of Biomedical Sciences, Academia Sinica · Institute of Sociology, Academia Sinica · +20 more institutions
Abstract
The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We reported that SJS/TEN caused by CBZ is strongly associated with the HLA-B*1502 gene in Han Chinese. Here, we extended our genetic study to different types of CBZ-cADRs (91 patients, including 60 patients with SJS/TEN, 13 patients with hypersensitivity syndrome and 18 with maculopapular exanthema versus 144 tolerant controls). We used MALDI-TOF mass spectrometry to screen the genetic association of 278 single nucleotide polymorphisms (SNPs), which cover the major…
Citation impact
- FWCI
- 20.39
- Percentile
- 100%
- References
- 36
Authors
19- WCWen‐Hung Chung
Institute of Biomedical Sciences, Academia Sinica, Institute of Sociology, Academia Sinica, Institute of Physics, Academia Sinica, Academia Sinica
- WCWen‐Hung Chung
National Yang Ming Chiao Tung University, Chang Gung Memorial Hospital, Institute of Molecular Biology, Academia Sinica
- SJShiou‐Hwa Jee
Genomics Research Center, Academia Sinica, National Taiwan University Hospital
- WCWenChieh ChenCorresponding
Genomics Research Center, Academia Sinica, Kaohsiung Chang Gung Memorial Hospital, Institute of Biomedical Sciences, Academia Sinica
- YCYun-Ting Chang
Taipei Veterans General Hospital, Genomics Research Center, Academia Sinica
Topics & keywords
- Toxic epidermal necrolysis
- Single-nucleotide polymorphism
- Carbamazepine
- Haplotype
- Medicine
- Odds ratio
- Allele
- Immunology
- Good health and well-being