Microbial Co-occurrence Relationships in the Human Microbiome
Vrije Universiteit Brussel · VIB-VUB Center for Structural Biology · +3 more institutions
Abstract
The healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional and symbiotic) between microbial inhabitants are important contributors to this variation. It is thus of interest to assess what relationships might exist among microbes and determine their underlying reasons. The initial Human Microbiome Project (HMP) cohort, comprising 239 individuals and 18 different microbial habitats, provides an unprecedented resource to detect, catalog, and analyze such relationships. Here, we applied an ensemble method based on multiple similarity measures in combination with generalized boosted linear models (GBLMs) to…
Citation impact
- FWCI
- 28.08
- Percentile
- 100%
- References
- 91
Authors
7- KFKaroline FaustCorresponding
Vrije Universiteit Brussel, VIB-VUB Center for Structural Biology
- JFJ. Fah SathirapongsasutiCorresponding
Harvard University
- JIJacques IzardCorresponding
Institute of Molecular Genetics, Harvard University
- NSNicola SegataCorresponding
Harvard University
- DGDirk GeversCorresponding
Broad Institute
Topics & keywords
- Biology
- Microbiome
- Fusobacteria
- Ecological niche
- Phylogenetic tree
- Niche
- Clade
- Ecology
Funding
- NSNational Science FoundationAwards: 1053486, DBI-1053486
- CACrohn's and Colitis Foundation of America
- CACrohn's and Colitis Foundation
- FWFonds Wetenschappelijk Onderzoek
- VRVlaamse regering
- NINational Institutes of HealthAwards: CA139193, ARO W911NF-11-1-0473, DBI-1053486, 1R01HG005969
- DODivision of Biological InfrastructureAward: DBI-1053486
- ARArmy Research OfficeAwards: W911NF-11-1-0473, W911NF, W911NF-11