Cellular pathophysiology of ischemic acute kidney injury

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.

• BA
  Brigham and Women's Hospital
• NI
  National Institutes of Health

  Awards: DK39773, DK38452, DK72381
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases