articleThe FASEB JournalJun 28, 2005Closed access

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D 3

AFAdrian F. GombartNBNiels BorregaardHPH. Phillip Koeffler

Cedars-Sinai Medical Center · University of Copenhagen · +2 more institutions

PubMed
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Abstract

The innate immune system of mammals provides a rapid response to repel assaults from numerous infectious agents including bacteria, viruses, fungi, and parasites. A major component of this system is a diverse combination of cationic antimicrobial peptides that include the alpha- and beta-defensins and cathelicidins. In this study, we show that 1,25-dihydroxyvitamin D3 and three of its analogs induced expression of the human cathelicidin antimicrobial peptide (CAMP) gene. This induction was observed in acute myeloid leukemia (AML), immortalized keratinocyte, and colon cancer cell lines, as well as normal human bone marrow (BM) -derived macrophages and fresh BM cells from two normal individuals and one AML…

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1,129
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Authors

3

Topics & keywords

Topics
Keywords
  • Cathelicidin
  • Calcitriol receptor
  • Biology
  • Innate immune system
  • Antimicrobial peptides
  • Cell biology
  • Myeloid
  • Cancer research
UN Sustainable Development Goals
  • Life in Land
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