Simplified criteria for the diagnosis of autoimmune hepatitis†
University Medical Center Hamburg-Eppendorf · Universität Hamburg · +12 more institutions
Abstract
UNLABELLED: Diagnosis of autoimmune hepatitis (AIH) may be challenging. However, early diagnosis is important because immunosuppression is life-saving. Diagnostic criteria of the International Autoimmune Hepatitis Group (IAIHG) were complex and purely meant for scientific purposes. This study of the IAIHG aims to define simplified diagnostic criteria for routine clinical practice. Candidate criteria included sex, age, autoantibodies, immunoglobulins, absence of viral hepatitis, and histology. The training set included 250 AIH patients and 193 controls from 11 centers worldwide. Scores were built from variables showing predictive ability in univariate analysis. Diagnostic value of each score was assessed by the…
Citation impact
- FWCI
- 36.67
- Percentile
- 100%
- References
- 37
Authors
18Topics & keywords
- Receiver operating characteristic
- Autoimmune hepatitis
- Medicine
- Cutoff
- Internal medicine
- Autoantibody
- Hepatitis
- Gastroenterology